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Massive Splenic Infarction and Portal Vein Thrombosis in Children With Chronic Myeloid Leukemia

Aksu, Tekin MD; Erdem, Arzu Y. MD; Fettah, Ali MD; Kaçar, Dilek MD; Avci, Zekai MD; Yarali, Nese MD; Tunc, Bahattin MD

Journal of Pediatric Hematology/Oncology: October 2014 - Volume 36 - Issue 7 - p e471–e472
doi: 10.1097/MPH.0000000000000204
Online Articles: Clinical and Laboratory Observations

Massive splenic infarction and portal vein thrombosis (PVT) due to chronic myeloid leukemia (CML) is extremely rare. We describe 2 children who were presented with massive splenic infarction and PVT in the course of CML. Massive splenic infarction and PVT treated with splenectomy in one and with medical treatment in another in whom PVT resolved by cytoreductive treatment, led to downsizing of spleen or splenectomy. Splenic infarct and PVT should be considered in CML patients with long-lasting severe abdominal pain despite appropriate medical attempts. Splenectomy should be spared for persistent symptoms and complications.

Department of Pediatric Hematology, Ankara Children’s Hematology and Oncology Hospital, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Ali Fettah, MD, Ankara Children's Hematology and Oncology Research Hospital, Ziraat Mah. İrfan Baştuǧ Cad. Kurtdereli Sk. No:10 Ankara, Turkey, Turkey (e-mail:

Received January 18, 2014

Accepted May 13, 2014

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