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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000215
Clinical and Laboratory Observations: PDF Only

Successful Hematopoietic Reconstitution by Unrelated Donor Cord Blood Transplantation in Children With Fanconi Anemia: Report of 3 Cases.

Jaing, Tang-Her MD; Chen, Shih-Hsiang MD; Yang, Chao-Ping MD; Hung, Iou-Jih MD; Chang, Tsung-Yen MD; Hsueh, Chuen MD

Published Ahead-of-Print
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To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m2/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).

(C) 2014 by Lippincott Williams & Wilkins.


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