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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000208
Clinical and Laboratory Observations: PDF Only

Diffuse Hemorrhagic Colitis in a Patient With Dyskeratosis Congenita After Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation.

Ehlert, Karoline MD; Rossig, Claudia MD; Groll, Andreas H. MD; Beyna, Torsten MD; Froehlich, Birgit MD; Juergens, Heribert MD

Published Ahead-of-Print
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Abstract

Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. Bone marrow failure in DC can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT). After a nonmyeloablative, matched unrelated donor transplant, the 21-year-old patient experienced severe lower gastrointestinal tract hemorrhage caused by diffuse colitis. The etiology remained unclear. Diffuse colitis with life-threatening hemorrhage has now been reported in 3 DC patients after unrelated allogeneic HSCT. To identify the underlying causes and the disease-specific risks, and to allow for prevention and/or optimal management, data should be prospectively collected.

(C) 2014 by Lippincott Williams & Wilkins.

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