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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000220
Original Article: PDF Only

Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia.

Ge, Jian PhD; Hu, Yan MSc; Gui, Yu MSc; Hou, Ruiqin MSc; Yang, Mingzhen PhD; Zeng, Qingshu MD; Xia, Ruixiang PhD

Open Access
Published Ahead-of-Print
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Abstract

Bone marrow-derived mesenchymal stem cells (BM-MSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4's functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF-1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.

This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

(C) 2014 by Lippincott Williams & Wilkins.

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