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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000132
Clinical and Laboratory Observations: PDF Only

Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement.

Wu, Susan Y. MSIII; McCavit, Timothy L. MD; Cederberg, Kevin MD; Galindo, Rene L. MD, PhD; Leavey, Patrick J. MD

Published Ahead-of-Print
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Abstract

Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

(C) 2014 by Lippincott Williams & Wilkins.

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