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Placental Mesenchymal Dysplasia and Fetal Hematologic Disorder

Koga, Hiroshi MD*; Makimura, Mika MD, PhD*; Tanaka, Hiromasa MD, PhD; Sumioki, Hisao MD, PhD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31829d4542
Online Articles: Clinical and Laboratory Observations

Placental mesenchymal dysplasia (PMD) is a rare, recently recognized placental vascular anomaly. About 20% of patients with this placental anomaly have Beckwith-Wiedemann syndrome. We report a case of a phenotypically normal neonate with anemia and thrombocytopenia associated with PMD. Histologic examination of the placenta showed findings consistent with PMD, including chorangioma. The patient’s hematologic abnormalities resolved during the week following birth. Normal phenotypic fetuses with PMD seem to exhibit hematologic disorders at birth in some cases, especially in the presence of chorangioma.

Author Information

Departments of *Pediatrics

Obstetrics and Gynecology, National Hospital Organization Beppu Medical Center, Oita, Japan

The authors declare no conflict of interest.

Reprints: Hiroshi Koga, MD, Department of Pediatrics, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Oita 874-0011, Japan (e-mail:

Received January 31, 2013

Accepted March 27, 2013

© 2014 by Lippincott Williams & Wilkins.