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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000196
Review Article

Langerhans Cell Sarcoma: Case Report and Review of World Literature

Zwerdling, Ted MD*; Won, Eric MD; Shane, Lisa MD*; Javahara, Ramin MD*; Jaffe, Ronald MD

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Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.

© 2014 by Lippincott Williams & Wilkins.


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