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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000196
Review Article

Langerhans Cell Sarcoma: Case Report and Review of World Literature

Zwerdling, Ted MD*; Won, Eric MD; Shane, Lisa MD*; Javahara, Ramin MD*; Jaffe, Ronald MD

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Abstract

Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.

Copyright © 2014 by Lippincott Williams & Wilkins

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