Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.
*Miller Children’s Hospital, Long Beach
†Department of Pediatrics, University of California, Irvine, CA
‡Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
The authors declare no conflict of interest.
Reprints: Ted Zwerdling, MD, Miller Children’s Hospital, 701 East 28th Street, Suite 202, Long Beach, CA 90806 (e-mail: firstname.lastname@example.org).
Received February 28, 2014
Accepted April 30, 2014