The use of image-guided percutaneous core needle biopsy (PCNB) to obtain tissue diagnosis of musculoskeletal lesions has become the standard of care in adult patients with a success rate of over 80%. Previous reports indicate a similar success rate in diagnosing pediatric solid tumors. In this large study, we analyzed >10 years of data in which PCNB was used for tissue diagnosis of musculoskeletal lesions in children; we evaluated the histopathologic accuracy, anesthetic requirements, and complications of these procedures. In 122 children, tissue diagnosis was successfully obtained in 82% of cases, and there were 0 complications associated with the procedure. There was a significantly higher PCNB diagnostic success rate in malignant lesions (93%). These data suggest that the use of PCNB is a safe and effective means of diagnosing musculoskeletal lesions in children.
*Department of Pediatrics, Division of Pediatric Hematology/Oncology
‡Department of Medicine, Division of Hematology/Oncology
§Department of Surgery, Division of Surgical Oncology
Departments of †Radiology
¶Orthopedic Surgery, University of California, Los Angeles, Los Angeles CA
N.F. is supported by a St. Baldrick’s Foundation Career Development Award.
The authors declare no conflict of interest.
Reprints: Noah Federman, MD, Department of Pediatrics, Division of Hematology/Oncology, Mattel Children’s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1752 (e-mail: firstname.lastname@example.org).
Received May 23, 2012
Accepted January 15, 2013