Skip Navigation LinksHome > May 2014 - Volume 36 - Issue 4 > Hemophagocytic Lymphohistiocytosis Associated With Parechovi...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000015
Online Articles: Clinical and Laboratory Observations

Hemophagocytic Lymphohistiocytosis Associated With Parechovirus 3 Infection

Aviner, Shraga MD, PhD; Sofer, Danit PhD; Shulman, Lester M. PhD; Bibi, Haim MD; Weitzman, Sheila MB, BCh, FRCP(C)

Collapse Box


Hemophagocytic lymphohistiocytosis (HLH) denotes the common final pathway of a potentially fatal hyperinflammatory condition of diverse etiologies. We describe the first case of documented HLH associated with human parechovirus 3. A monoallelic Ala91Val mutation was found in the PRF1 gene, but the contribution of this mutation to HLH remains controversial. The diagnosis, based on accepted criteria, was established early in the course of the disease and led to successful treatment and complete recovery. The awareness of this new association is clinically important in facilitating early treatment, preventing organ damage, and increasing the likelihood of complete recovery.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.