Skip Navigation LinksHome > May 2014 - Volume 36 - Issue 4 > Hemophagocytic Lymphohistiocytosis Associated With Parechovi...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000015
Online Articles: Clinical and Laboratory Observations

Hemophagocytic Lymphohistiocytosis Associated With Parechovirus 3 Infection

Aviner, Shraga MD, PhD*,†; Sofer, Danit PhD; Shulman, Lester M. PhD‡,§; Bibi, Haim MD*,†; Weitzman, Sheila MB, BCh, FRCP(C)

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) denotes the common final pathway of a potentially fatal hyperinflammatory condition of diverse etiologies. We describe the first case of documented HLH associated with human parechovirus 3. A monoallelic Ala91Val mutation was found in the PRF1 gene, but the contribution of this mutation to HLH remains controversial. The diagnosis, based on accepted criteria, was established early in the course of the disease and led to successful treatment and complete recovery. The awareness of this new association is clinically important in facilitating early treatment, preventing organ damage, and increasing the likelihood of complete recovery.

Copyright © 2013 by Lippincott Williams & Wilkins

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