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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31828e51cc
Online Articles: Clinical and Laboratory Observations

Vitamin D Deficiency and Hypocalcemia in an Infant With Newly Diagnosed AML

Cook, Cathleen MD*; Bernardo, Valeria PharmD; Shelso, John MD; Ribeiro, Raul C. MD§

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Abstract

We report a 4-month-old male presenting with hypocalcemia, hyperleukocytosis, and newly diagnosed acute myeloid leukemia. He received chemical leukoreduction through low-dosed cytarabine, with appropriate decrease in his white blood cell count and development of subsequent symptomatic hypocalcemia, which did not normalize until the underlying vitamin D deficiency was addressed. A single dose of cholecalciferol raised the serum calcium concentration to an appropriate level within 48 hours. For infants with newly diagnosed leukemia and prolonged hypocalcemia, vitamin D deficiency should be considered in the differential diagnosis and managed appropriately.

Copyright © 2013 by Lippincott Williams & Wilkins

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