Skip Navigation LinksHome > March 2014 - Volume 36 - Issue 2 > Rituximab in Lymphomatoid Granulomatosis
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31827e63a6
Online Articles: Clinical and Laboratory Observations

Rituximab in Lymphomatoid Granulomatosis

Hernández-Marqués, Carmen MD*; Lassaletta, Alvaro MD*; Torrelo, Antonio MD; López-Pino, Miguel Ángel MD; Álvarez-Coca, Javier MD§; De Prada, Inmaculada MD; Hernández-Martín, Ángela MD; Madero, Luis MD*

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Abstract

Background:

Lymphomatoid granulomatosis (LG) is an Epstein-Barr virus–associated, multisystemic disease that combines a granulomatous inflammatory process with lymphoproliferative potential. It is a rare disorder with a variable clinical presentation ranging from an indolent process to an aggressive B-cell lymphoma. Outcome is unpredictable, and a standard treatment has not yet been established. Cases treated with rituximab, an anti-CD20 monoclonal antibody, have been reported with variable results.

Observation:

We report on 2 children with LG treated with rituximab and review the literature. The first patient had good response but the second did not.

Conclusions:

Rituximab is a treatment option for LG.

Copyright © 2013 by Lippincott Williams & Wilkins

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