Skip Navigation LinksHome > March 2014 - Volume 36 - Issue 2 > Ectopic Neuroblastoma in Monozygotic Twins With Different Ag...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318290c686
Clinical and Laboratory Observations

Ectopic Neuroblastoma in Monozygotic Twins With Different Ages of Onset: Possible Twin-to-Twin Metastasis In Utero With Distinct Genetic Alterations After Birth

Taketani, Takeshi MD*,†; Takita, Junko MD; Ueyama, Junichi MD§; Kanai, Rie MD; Kumori, Koji MD; Maruyama, Riruke MD; Hayashi, Kazuhiko MD#; Ogawa, Seishi MD**; Fukuda, Seiji MD; Yamaguchi, Seiji MD

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Abstract

We describe neuroblastoma (NB) in monozygotic twins whose ages at the onset of the disease had a 3-year interval. The primary tumor site of twin 1 was the adrenal gland, whereas that of twin 2 was the jejunum/mesentery. MYCN amplification, DNA index, ALK mutation, and copy number alterations of DNA were different between each primary tumor. NB in ectopic sites may have resulted from twin-to-twin metastasis through vascular anastamoses in the placenta. The pathogenesis of this NB involved a premalignant stage of NB during the fetal development and subsequent molecular alterations after birth, resulting in NBs that were phenotypically similar but genetically different.

Copyright © 2013 by Lippincott Williams & Wilkins

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