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Clear Cell Adenocarcinoma of the Uterine Cervix: A Case Report and Review of the Literature

Baykara, Meltem MD; Benekli, Mustafa MD; Erdem, Ozlem MD; Taskiran, Cagatay MD; Demirci, Umut MD; Vargol, Erdem MD; Gunaydin, Yusuf MD; Coskun, Ugur MD; Ozet, Ahmet MD; Buyukberber, Suleyman MD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318290cb1b
Online Articles: Clinical and Laboratory Observations

We report an extremely rare case of a patient with clear cell carcinoma of the cervix who had no history of in utero diethylstilbestrol (DES) exposure. Although clear cell adenocarcinoma is an uncommon tumor, it must be considered in the differential diagnosis in young women and children who have cervico-vaginal lesions even without in utero DES exposure history. We present the case of 2 girls, a 14-year-old and a 16-year-old, who were admitted to hospital because of intermittent vaginal bleeding and the presence of a cervical mass diagnosed as clear cell cervix carcinoma. Neither of them had a history of exposure to DES.

Author Information

*Department of Medical Oncology, Sakarya University Training and Research Hospital, Sakarya

Department of Medical Oncology, Gazi University Medical Faculty

Department of Pathology, Gazi University Medical Faculty

§Department of Obstetrics and Gynecology, Gazi University Medical Faculty

Department of Medical Oncology, Ataturk Education and Research Hospital, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Meltem Baykara, MD, Department of Medical Oncology, Sakarya University Training and Research Hospital, Korucuk, Sakarya, 54000 Turkey (e-mail:

Received December 25, 2012

Accepted March 3, 2013

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