Skip Navigation LinksHome > January 2014 - Volume 36 - Issue 1 > Remission and Relapse of Hemophagocytic Lymphohistiocytosis...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318271c963
Online Articles: Clinical and Laboratory Observations

Remission and Relapse of Hemophagocytic Lymphohistiocytosis in a Patient Harboring a PRF1 Homozygous Mutation: A Case Report

Huang, Zhizhuo MD*; Wang, Yali MSc*; Xie, Zhengde MD*; Shen, Kunling MD

Collapse Box


The aim of this paper was to describe a case of familial hemophagocytic lymphohistiocytosis (HLH) in a pediatric patient with a PRF1 homozygous mutation. An 8-year-old boy diagnosed with HLH was in remission after undergoing nonspecific treatment; however, merely 2 months later, he was presented at our hospital with a relapse of HLH. His genetic analysis showed that he had a homozygous mutation c.1066C>T in the PRF1 gene. Timely distinction of primary HLH from secondary HLH is critical.

© 2014 by Lippincott Williams & Wilkins.


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.