Skip Navigation LinksHome > January 2014 - Volume 36 - Issue 1 > Pediatric Myelodysplastic Syndromes: They Do Exist!
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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000046
Invited Review Article

Pediatric Myelodysplastic Syndromes: They Do Exist!

Glaubach, Taly MD*,†; Robinson, Lisa J. MD; Corey, Seth J. MD, MPH*,†,§

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Abstract

One of the most common hematologic malignancies in adults, myelodysplastic syndrome (MDS) is a heterogenous group of clonal disorders characterized by peripheral cytopenia(s) and normal or hypercellular bone marrow with dysplasia in ≥1 blood cell lineages. MDS frequently evolves to secondary acute myeloid leukemia with poor prognosis. Although uncommon among pediatric hematologic malignancies, both de novo and secondary MDS occur in children and may be the first presentation of an inherited bone marrow failure syndrome. Unlike its adult counterpart, pediatric MDS is more frequently associated with hypocellular bone marrow and monosomy 7. Refractory cytopenia is more typical than refractory anemia, as seen in the elderly. Its recognition and management can be quite challenging and requires the expertise of an experienced hematopathologist. In this review, we describe the epidemiology, genetics, and clinical spectrum of pediatric MDS along with its diagnostic and therapeutic challenges. We also compare and contrast pediatric and adult MDS.

© 2014 by Lippincott Williams & Wilkins.

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