Skip Navigation LinksHome > January 2014 - Volume 36 - Issue 1 > Expression of the Novel All-trans Retinoic Acid-related Resi...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31828e5d73
Original Articles

Expression of the Novel All-trans Retinoic Acid-related Resistance Gene HA117 in Pediatric Solid Tumors

Duan, Wenjuan MD*; Jin, Xianqing PhD*,†,‡,§,∥; Xiu, Youhua PhD; Wang, Shiqi MD*; Zhu, Jin MD#; Liu, Hang PhD*; Ding, Xionghui PhD*; Jin, Xin MD*; Zhao, Zhanbo MD*; Wang, Xiuliang MD*

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Abstract

This study aimed to detect the protein expression of HA117 in pediatric solid tumors. Immunohistochemistry was performed to detect the expression of HA117 and P-gp in pediatric solid tumors. In Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), nephroblastoma (WT), and neuroblastoma (NB), the positive expression rate of HA117 was 65.4%, 58.3%, 81.3%, and 74.1%, and that of P-gp was 57.7%, 70.8%, 65.6%, and 66.7%, respectively. HA117 expression was closely related to the clinical stage of HL (P=0.004) and to the International Prognostic Index score, mediastinal lesions, and clinical stages of NHL (P=0.01, 0.03, and 0.01). The expression of HA117 in WT was higher than in adjacent normal tissues, but there was no statistical significance (P=0.21). The positive expression of HA117 in NB was markedly higher than that in normal tissues (P=0.002), which closely associated with histologic type and lymph node metastasis (P=0.03 and 0.001). Spearman correlation analysis revealed that HA117 expression was not correlated with P-gp in these 4 tumors. This suggests that HA117 might be an important resistance gene in pediatric solid tumors. The mechanism underlying the resistance to all-trans retinoic acid conferred by HA117 is different from that of P-gp.

© 2014 by Lippincott Williams & Wilkins.

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