Skip Navigation LinksHome > January 2014 - Volume 36 - Issue 1 > Chronic Residual Lesions in Metastatic Medulloblastoma Patie...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182843b40
Clinical and Laboratory Observations

Chronic Residual Lesions in Metastatic Medulloblastoma Patients

Fried, Iris MD*,†; Huang, Annie MD, PhD*; Bartels, Ute MD*; Tabori, Uri MD*; Laperriere, Normand MD; Dirks, Peter MD, PhD§; Bouffet, Eric MD*

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Abstract

In a retrospective review of 24 metastatic medulloblastoma patients whose treatment included craniospinal irradiation, 5 patients presented with gross residual abnormalities at completion of therapy. This report describes 2 medulloblastoma patients with persistent residual abnormalities on serial follow-up imaging studies. The patients aged 2 and 2.5 years old at the time of diagnosis underwent surgery followed by multiagent chemotherapy. One patient progressed on therapy and underwent salvage craniospinal radiation. The second showed residual tumor on end of treatment imaging and received low-dose craniospinal irradiation. Despite persistent magnetic resonance imaging findings, the patients are alive and well 13 and 7 years after diagnosis with no further treatment applied. The nature of these residual abnormalities is discussed.

© 2014 by Lippincott Williams & Wilkins.

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