Skip Navigation LinksHome > August 2013 - Volume 35 - Issue 6 > Successful Treatment of Diffuse Large B-Cell Lymphoma in a P...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182804d59
Clinical and Laboratory Observations

Successful Treatment of Diffuse Large B-Cell Lymphoma in a Patient With Ataxia Telangiectasia Using Rituximab

Machida, Shizuka MD*; Tomizawa, Daisuke MD, PhD*; Tamaichi, Hiroyuki MD*,†; Okawa, Teppei MD*; Endo, Akifumi MD*; Imai, Kohsuke MD, PhD*; Nagasawa, Masayuki MD, PhD*; Morio, Tomohiro MD, PhD*; Mizutani, Shuki MD, PhD*; Takagi, Masatoshi MD, PhD*

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Abstract

Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by cerebellar ataxia, telangiectasia, immune defect, and predisposition to leukemia/lymphoma. Because of their hypersensitivity to DNA-damaging agents, patients with A-T may require special consideration. However, an optimal strategy for these patients has not been established. Here, we describe an A-T female with diffuse large B-cell lymphoma successfully treated with rituximab combined with reduced-dose chemotherapy. Given the high incidence of hematopoietic malignancies in patients with A-T, and the hypersensitivity of these patients to DNA-damaging agents, we discuss whether a reduced-dose chemotherapy with a molecular targeting agent may be of merit.

Copyright © 2013 by Lippincott Williams & Wilkins

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