Skip Navigation LinksHome > August 2013 - Volume 35 - Issue 6 > Congenital CMV With LAD Type 1 and NK Cell Deficiency
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31827e57b2
Original Articles

Congenital CMV With LAD Type 1 and NK Cell Deficiency

Rai, Narendra MD*; Thakur, Neha MD

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Abstract

We report a rare case of congenital cytomegalovirus (CMV) in a patient who was subsequently diagnosed as leukocyte adhesion defect type 1 with natural killer cell deficiency. The clinical course was complicated by severe CMV pneumonitis during the newborn period. Thereafter the infant suffered from recurrent skin infections without pus formation, otitis media, and bronchopneumonia since 3 months of age. The patient had congenital CMV infection as urine and blood plasma was positive for CMV from day 12 onward. Neutrophil chemotaxis studies showed a decrease in directed chemotaxis. Neutrophils were dyspoetic and nonfunctional lacking HLA DR, CD11c, and CD18. Lymphocytes were polyclonal but lacked CD56, CD16, and surface membrane immunoglobulin.

Copyright © 2013 by Lippincott Williams & Wilkins

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