Skip Navigation LinksHome > July 2013 - Volume 35 - Issue 5 > Successful Treatment of Recurrent Pediatric Inflammatory Myo...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182915cef
Clinical and Laboratory Observations

Successful Treatment of Recurrent Pediatric Inflammatory Myofibroblastic Tumor in a Single Patient With a Novel Chemotherapeutic Regimen Containing Celecoxib

Johnson, Kevin MD*; Notrica, David M. MD*,†,‡; Carpentieri, David MD§,∥,¶; Jaroszewski, Dawn MD#; Henry, Michael M. MD**

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Abstract

Inflammatory myofibroblastic tumors are rare tumors characterized as low-to-intermediate grade sarcomas. This is a case of a 7-year-old male with a 5-cm lung mass, which recurred 11 months after complete resection. The recurrence manifested as multifocal metastatic disease involving the ipsilateral parietal and visceral pleura. A novel chemotherapeutic regimen, which included vincristine, ifosfamide, doxorubicin, and celecoxib was utilized for the disease recurrence. The patient had complete and durable remission of the disease and has been disease-free for >4 years. This novel regimen including a cyclooxygenase 2 inhibitor may be an effective regimen for metastatic inflammatory myofibroblastic tumors.

Copyright © 2013 by Lippincott Williams & Wilkins

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