Secondary neoplasms are not reported frequently after neuroblastoma, which until recently was a cancer with limited long-term survival. Although salivary gland tumors in children and adolescents may be idiopathic, they are seen more often after head and neck radiation. We report a child with stage 4 neuroblastoma treated with high-dose multiagent chemotherapy without radiation therapy to his neck who, within 1 year of treatment, developed a low-grade but large and locally aggressive mucoepidermoid carcinoma of his parotid gland further characterized by a t(11;19)(q21;p13.1). Our patient extends the spectrum of secondary neoplasms after neuroblastoma.
*Department of Pediatrics
†Division of Pediatric Hematology Oncology
‡Departments of Otolaryngology/Head and Neck Surgery
∥Pathology and Genetics
¶Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC
The authors declare no conflict of interest.
Reprints: Julie Blatt, MD, Department of Pediatrics, Division of Pediatric Hematology Oncology, University of North Carolina School of Medicine, 170 Manning Dr, POB 1185A CB 7236 Chapel Hill, NC 27599-7236 (e-mail: email@example.com).
Received November 1, 2011
Accepted December 13, 2011