Skip Navigation LinksHome > May 2013 - Volume 35 - Issue 4 > Transient Effect of Anti-CD20 Therapy in a Child With 22q11....
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31828be602
Clinical and Laboratory Observations

Transient Effect of Anti-CD20 Therapy in a Child With 22q11.2 Deletion Syndrome and Severe Steroid Refractory Cytopenias: A Case Report

Soldatou, Alexandra MD, PhD*; Anastassiou, Theodora MD, PhD; Vougiouka, Olga MD, PhD*; Goussetis, Evgenios MD, PhD; Kossiva, Lydia MD, PhD*

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We report on the development of steroid-refractory recurrent cytopenias in a child with 22q11.2 deletion syndrome. His first hematological complication was autoimmune hemolytic anemia at 3 months of age. Thereafter, he developed severe autoimmune cytopenias of all 3 hematological lineages with poor response to steroids and intravenous immunoglobulin. At the age of 2½ years, a course of anti-CD20 therapy (Rituximab) was given with transient hematological recovery. Because of persistent symptoms, bone marrow transplantation from a matched unrelated donor was performed. Although the data in the use of anti-CD20 therapy in children with 22q11.2 deletion syndrome and autoimmune cytopenias are limited, our experience suggests its potential benefit.

© 2013 Lippincott Williams & Wilkins, Inc.


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