Skip Navigation LinksHome > May 2013 - Volume 35 - Issue 4 > Iron Deficiency Anemia Due to Lymphocytic Gastritis With Hel...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318286d129
Clinical and Laboratory Observations

Iron Deficiency Anemia Due to Lymphocytic Gastritis With Helicobacter pylori Infection in Childhood: Case Report

Santalha, Marta F.F. Jr MD*; Costa, Emília MD; Miguel, Natalina MD; Vizcaíno, Ramón MD; Barbot, José MD; Pereira, Fernando MD§

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Abstract

Lymphocytic gastritis (LG) is a chronic inflammatory process of poorly understood pathogenesis. We report the case of a 12-year-old premenstrual girl with refractory iron deficiency anemia in which the oral iron absorption challenge suggested iron malabsorption. Laboratory studies ruled out celiac disease and autoimmune gastritis, and carbon-13 urea breath test for Helicobacter pylori was also negative. Upper endoscopy with gastric body and antral mucosa biopsies revealed a LG with focal intestinal metaplasia and H. pylori infection. H. pylori eradication was undertaken with success and 3 months later her hematologic parameters normalized. Histologic reevaluation showed disappearance of LG. This case shows that investigation of malabsorption disease in the presence of refractory iron deficiency anemia can lead to the diagnosis of important gastric diseases, even in the absence of gastrointestinal symptoms. This nonceliac child was diagnosed with a severe histopathologic pattern of LG, with potential risk of malignant transformation, which was completely reverted with adequate H. pylori eradication treatment.

© 2013 Lippincott Williams & Wilkins, Inc.

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