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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182707e67
Online Articles: Original Articles

Sustained Response to Weekly Vinblastine in 2 Children With Pilomyxoid Astrocytoma Associated With Diencephalic Syndrome

Singh, Gurpreet MD*; Wei, Xing Chang MD; Hader, Walter MD; Chan, Jennifer A. MD§; Bouffet, Eric MD; Lafay-Cousin, Lucie MD, MSc*

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Abstract

Diencephalic syndrome (DS) related to hypothalamic/chiasmatic region tumor has mainly been reported with low-grade glioma. We described 2 young children with DS related to pilomyxoid astrocytoma. Despite the recognized more agressive clinical behavior of this histologic subtype, we report successful resolution of DS and sustained tumor response with prolonged use of single-agent vinblastine.

© 2013 Lippincott Williams & Wilkins, Inc.

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