Introduction: Short hemato-oncologic procedures are often painful in children, and sedation should be performed outside the operating room.
Aim: The study aims to compare the effects of remifentanil with those of fentanyl administered during short hemato-oncologic interventions in children.
Materials and Methods: A prospective, randomized study was planned for 29 ASA I to III children (aged, 2 to 18 y) to undergo a total of 60 short oncologic interventions. The patients were placed into 2 groups: propofol-remifentanil (group PR) and propofol-fentanyl (group PF). Group PR was first administered propofol (2 mg/kg) and then remifentanil bolus (0.5 μg/kg). Group PF was first administered propofol (2 mg/kg) and then fentanyl bolus (0.5 μg/kg). Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, respiratory rate, peripheral oxygen saturation, and heart rate were recorded every 3 minutes during the intervention and every 5 minutes after the operation. Postanesthetic recovery scores, eye-opening time to speech, and recovery time were recorded.
Results: Comparison of diastolic arterial pressure in groups at minute 3 of the procedure showed significant difference (P<0.05). Eye-opening to speech (P=0.043) and recovery times (P=0.002) were shorter in group PR.
Conclusions: During short hemato-oncologic interventions in children, the PR combination is a suitable one for early recovery.
Departments of *Anesthesiology and Intensive Care
‡Pediatric Oncology, School of Medicine, Dokuz Eylül University, İzmir, Turkey
Supported by the Department of Anesthesiology and Reanimation and I.E.I.
I.E.I. and L.İ.: designed the study and wrote the protocol. Ş.Y., D.G., M.A., and D.İ.: managed the literature searches, data collection, data interpretation, and undertook the statistical analysis. I.E.I. and L.İ.: wrote the first draft of the manuscript. I.E.I., L.İ, Ş.Y., D.G., M.A., and D.İ. have contributed and have approved the final manuscript.
The authors declare no conflict of interest.
Reprints: Leyla İyilikci, MD, Department of Anesthesiology and Intensive Care, School of Medicine, Dokuz Eylül University, İnciralti 35340, İzmir, Turkey (e-mail: email@example.com).
Received November 29, 2011
Accepted October 17, 2012