Life-threatening Paraneoplastic Syndrome in a Child With Sarcoma of the Liver Cured by Emergency ResectionFricchione, Marielle J. MD; Glenn, Nicole MD; Follmer, Rachel MD; Kent, Paul M. MDJournal of Pediatric Hematology/Oncology: March 2013 - Volume 35 - Issue 2 - p 153–155 doi: 10.1097/MPH.0b013e318266bf55 Clinical and Laboratory Observations Abstract Author Information Abstract We believe this to be the first case of life-threatening paraneoplastic syndrome (PNS) in a child with undifferentiated embryonal sarcoma of the liver (UESL). We report a case of a 9-year-old child with UESL believed to be unresectable at presentation, who experienced life-threatening, refractory long QTc syndrome, Torsades de pointes, fevers of unknown origin, and secretory diarrhea necessitating emergency surgery. After failure of intravenous immunoglobulin and high-dose steroids to control PNS and despite pancytopenia from chemotherapy, very aggressive surgical resection was life saving and led to rapid resolution of PNS. Author Information *Rush University Medical Center †Chicago Medical School, Chicago, IL The authors declare no conflict of interest. Reprints: Marielle J. Fricchione, MD, 1653 W. Congress Parkway, Suite 710, Chicago, IL 60612 (e-mail: email@example.com). Received September 14, 2011 Accepted June 26, 2012 Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.