Skip Navigation LinksHome > March 2013 - Volume 35 - Issue 2 > Cerebral Toxoplasmosis After Tandem High-dose Chemotherapy a...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182677e84
Online Articles: Original Articles

Cerebral Toxoplasmosis After Tandem High-dose Chemotherapy and Autologous Hematopoietic Cell Transplant for Neuroblastoma

Voegele, Laura MD*; Cheerva, Alexandra C. MD, MS; Bertolone, Salvatore MD

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Abstract

Toxoplasmosis is a well-recognized life-threatening complication of hematopoietic cell transplantation (HCT). This report describes a pediatric patient with stage 4 neuroblastoma who developed cerebral toxoplasmosis after tandem high-dose chemotherapy with autologous HCT. Toxoplasmosis is rare in patients undergoing autologous HCT; however, tandem autologous HCT is more immunosuppressive than a single autologous HCT. Toxoplasmosis is a potential complication in autologous as well as allogeneic transplants, and should be considered in any post-HCT patient with neurological dysfunction. Rapid diagnosis and immediate antimicrobial treatment are crucial to avoid morbidity and mortality. Evaluation of toxoplasma serology should be standard in all patients undergoing tandem autologous HCT and seropositive patients should be started on appropriate prophylactic therapy.

© 2013 Lippincott Williams & Wilkins, Inc.

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