Skip Navigation LinksHome > January 2013 - Volume 35 - Issue 1 > Use of Gemcitabine With Multi-stage Surgical Resection as Su...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182707577
Online Articles: Clinical and Laboratory Observations

Use of Gemcitabine With Multi-stage Surgical Resection as Successful Second-line Treatment of Metastatic Pancreatoblastoma

Belletrutti, Mark J. MD; Bigam, David MD; Bhargava, Ravi MD; Grundy, Paul MD

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Pancreatoblastoma is a rare pediatric pancreatic malignancy. It confers a worse prognosis if there is metastatic or unresectable disease. We report a case of a 12-year-old boy who presented with pancreatoblastoma of the head of the pancreas with multiple intrahepatic metastases. We successfully treated him using aggressive chemotherapy, multi-stage surgery, and gemcitabine chemotherapy, which has not been described as treatment for pancreatoblastoma. Rare childhood malignancies such as pancreatoblastoma require a coordinated, multidisciplinary approach and frequent reassessment of therapeutic interventions. Complete surgical resection is important for cure and may require complex, aggressive, multiple-stage surgical procedures with concurrent or novel chemotherapy.

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.


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