Skip Navigation LinksHome > January 2013 - Volume 35 - Issue 1 > Probable Cytarabine-induced Acral Erythema: Report of 2 Ped...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182580ba0
Online Articles: Clinical and Laboratory Observations

Probable Cytarabine-induced Acral Erythema: Report of 2 Pediatric Cases

Ozmen, Serap MD; Dogru, Mahmut MD; Bozkurt, Ceyhun MD; Kocaoglu, Ayse Ceyda MD

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Acral erythema (palmoplantar erythrodysesthesia) is a localized skin side effect that is seen most often in patients receiving cytarabine, liposomal pegylated doxorubicin, capecitabine, and 5-fluorouracil. It is characterized by painful erythema of both palms and soles with symmetrically well-defined borders, which may progress to bullae formation and desquamation. It is frequently occurred in patients with acute myeloid leukemia and lymphoma. Here, we reported 2 cases of acral erythema that developed during cytarabin-etoposide and cytarabine-mitoxantrone combination treatment for acute myeloid leukemia. Although rarely reported in children, pediatricians should especially be aware of this reaction when taking care of children who receive chemotherapy.

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.


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