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Importance of Adjusting Dual-energy X-Ray Output for Body Size: An Example From Survivors of Childhood Acute Lymphoblastic Leukemia

Aldhafiri, Fahad MSc; Al-Nasser, Abdallah MB, ChB; Al-Sugair, Abdulaziz MB ChB; Khanna, Sheila PhD; Ahmed, Faisal S. MD, MRCPCH; Al-Mutairi, Hanan RD; Reilly, John J. PhD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182678ed8
Online Articles: Clinical and Laboratory Observations
Abstract

We compared DXA whole body and lumbar spine bone mineral density (BMD) using manufacturers software with a body size correction which derived bone mineral content (BMC) for bone area in survivors of acute lymphoblastic leukemia in Saudi Arabia (n=51, mean age 13.5 y). With no corrections, 29 patients (57%) had lumbar spine BMD Z score <−1.0 and 21 (41%) had whole body BMD Z score <−2. After correction, only 6 (12%) had lumbar spine BMC Z score <−1.0 and 4 (8%) had whole body BMC Z score <−2. Agreement between the methods was “poor” by weighted κ analysis.

Author Information

*College of Medical, Veterinary, and Life Sciences, University of Glasgow

Bone and Endocrine Research Group, Royal Hospital for Sick Children

§School of Psychological Sciences and Health, University of Strathclyde, Glasgow, Scotland

King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Supported by Al Majma’ah University and the Scottish Funding Council.

The authors declare no conflict of interest.

Reprints: John J. Reilly, PhD, School of Psychological Sciences and Health, University of Strathclyde, Glasgow G13 1PP, Scotland (e-mail: john.j.reilly@strath.ac.uk).

Received December 4, 2011

Accepted March 28, 2012

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.