Skip Navigation LinksHome > January 2013 - Volume 35 - Issue 1 > Immunologic Consequences of Chemotherapy for Acute Myeloid L...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318266c0c8
Original Articles

Immunologic Consequences of Chemotherapy for Acute Myeloid Leukemia

Reilly, Anne MD*; Kersun, Leslie S. MD*; Luning Prak, Eline MD, PhD; Boyer, Jean PhD; McDonald, Kenyetta BS§; Jawad, Abbas F. PhD; Sullivan, Kathleen E. MD, PhD§

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Abstract

There are few data characterizing the immunologic consequences of chemotherapy for acute myeloid leukemia (AML) and almost nothing is known about the effects of chemotherapy in a pediatric AML cohort. We identified T-cell subsets, B-cell subsets, and used Enzyme-linked immunosorbent spot analyses to define the function of T cells and B cells in 7 pediatric patients with AML on chemotherapy. The data show that the effects of chemotherapy disproportionately target the B cell and depletion of B cells is associated with impaired responses to the inactivated influenza vaccine. Diminished T-cell numbers were also observed although the magnitude of the effect was less than what was seen for B cells. Furthermore, measures of T-cell function were largely intact. We conclude that humoral immunity is significantly affected by chemotherapy for AML.

© 2013 Lippincott Williams & Wilkins, Inc.

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