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ITP in Children: Pathophysiology and Current Treatment Approaches

D’Orazio, John A. MD, PhD; Neely, Jessica BS; Farhoudi, Nina BS, PharmD

Journal of Pediatric Hematology/Oncology: January 2013 - Volume 35 - Issue 1 - p 1–13
doi: 10.1097/MPH.0b013e318271f457
Original Articles

Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.

Department of Pediatrics, Division of Hematology-Oncology and The Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY

Supported by The University of Kentucky and the Markey Cancer Center.

The authors declare no conflict of interest.

Reprints: John D’Orazio, MD, PhD, Department of Pediatrics, Division of Hematology-Oncology and The Markey Cancer Center, University of Kentucky College of Medicine, Combs Research Building, 800 Rose Street, Lexington, KY 40536-0096 (e-mail: jdorazio@uky.edu).

Received February 10, 2012

Accepted July 13, 2012

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.