Skip Navigation LinksHome > January 2013 - Volume 35 - Issue 1 > Chemotherapy for Initial Induction Failures in Childhood Acu...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318279afdd
Original Articles

Chemotherapy for Initial Induction Failures in Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study (POG 8764)

Joyce, Michael J. MD*; Pollock, Brad H. PhD; Devidas, Meenakshi PhD; Buchanan, George R. MD§; Camitta, Bruce MD

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Abstract

Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m2/day IV) for 3 days and cytosine arabinoside (100 mg/m2/day continuous IV infusion) for 7 days. There were 3 complete and 3 partial responses. Two additional patients achieved a complete response after a second, shorter course of the same agents. Although VM26 plus Ara-C is an active combination for treatment of acute lymphocytic leukemia induction failure, it does not appear as effective as in the initial report. Better treatments for this problem are needed.

© 2013 Lippincott Williams & Wilkins, Inc.

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