Skip Navigation LinksHome > January 2013 - Volume 35 - Issue 1 > Chemotherapy for Initial Induction Failures in Childhood Acu...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318279afdd
Original Articles

Chemotherapy for Initial Induction Failures in Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study (POG 8764)

Joyce, Michael J. MD; Pollock, Brad H. PhD; Devidas, Meenakshi PhD; Buchanan, George R. MD; Camitta, Bruce MD

Collapse Box


Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m2/day IV) for 3 days and cytosine arabinoside (100 mg/m2/day continuous IV infusion) for 7 days. There were 3 complete and 3 partial responses. Two additional patients achieved a complete response after a second, shorter course of the same agents. Although VM26 plus Ara-C is an active combination for treatment of acute lymphocytic leukemia induction failure, it does not appear as effective as in the initial report. Better treatments for this problem are needed.

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.