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Total Skin Electron Beam Radiation in a Pediatric Patient With Leukemia Cutis: A Case Report

Majd, Nazanin K. MD, PhD; Jain, Sheena K. MD; Murphy, Mike C. MD; Dugas, Joseph P. PhD; Hager, Frederick MS; Abdulrahman, Ramzi MD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182678e9f
Clinical and Laboratory Observations
Abstract

Leukemia cutis, a form of extramedullary leukemia involving the skin, is a poor prognostic marker and indicator of imminent hematologic relapse and chemotherapeutic resistance in leukemia patients. Although total skin electron beam radiotherapy is commonly recommended for patients with leukemia cutis, its role and effectiveness remains unclear. Here we describe a 19-month-old infant with acute myelogenous leukemia first diagnosed at 15 months of age. It relapsed in her skin at 18 months of age, associated with raised hyperpigmented lesions on her chest and scalp. Radiation treatment to the total skin surface with radiation therapy resulted in relief of her symptoms before relapse in the bone marrow.

Author Information

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas

*Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX

The authors declare no conflict of interest.

Reprints: Ramzi Abdulrahman, MD, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9183 (e-mail: ramzi.abdulrahman@utsouthwestern.edu).

Received June 26, 2011

Accepted January 3, 2012

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.