Skip Navigation LinksHome > October 2012 - Volume 34 - Issue 7 > Spontaneous Remission of Childhood Acute Marrow Fibrosis and...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318257a172
Clinical and Laboratory Observations

Spontaneous Remission of Childhood Acute Marrow Fibrosis and Megakaryoblastic Leukemia

Elhasid, Ronit MD*; Tohami, Tali PhD; Moustafa-Hawash, Nivin MSc; Ben-Ezra, Jonathan MD§; Izraeli, Shai MD; Sayar, Dror MD

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Abstract

Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. One had sepsis and was treated with antibiotics and blood products, whereas the other received only blood products. Remission was spontaneous, without chemotherapy treatment. Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections. Natural killer and cytotoxic T cells transfused with blood products might have also triggered an immune response.

© 2012 Lippincott Williams & Wilkins, Inc.

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