Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disorder. There have been a few reports on HLH secondary to scrub typhus in adults. Here, we describe the case of a 9-year-old Korean girl who presented with the typical findings of HLH. Despite adequate antirickettsial and HLH treatment, the neurological impairment worsened and remained. This is the first case report of severe neurological impairment resulting from the very rare association of HLH with scrub typhus. Therefore, in endemic areas, a high index of suspicion for scrub typhus is warranted in patients presenting with HLH.
Departments of *Pediatrics
‡Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Chollanamdo, Korea
The authors declare no conflict of interest.
Reprints: Hoon Kook, MD, PhD, Department of Pediatrics, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, 160 Ilsim-Ri, Hwasun-Gun, Gwangju, Chollanamdo 519-809, Korea (South) (e-mail: email@example.com).
Received July 20, 2011
Accepted March 27, 2012