Skip Navigation LinksHome > October 2012 - Volume 34 - Issue 7 > Quantification of Plasma and Bone Marrow VEGF and Angiopoiet...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318257f2a8
Original Articles

Quantification of Plasma and Bone Marrow VEGF and Angiopoietin-2 Levels in Pediatric Malignancies

Hintsala, Emilia BSc*; Bono, Petri MD; Andersson, Sture MD; Kivivuori, Sanna-Maria MD*

Collapse Box

Abstract

Introduction: Data on angiogenesis in pediatric patients with malignancy are scarce. Our aim was to study angiogenic growth factors vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang2) in pediatric oncological patients at diagnosis and a few months after the beginning of the therapy.

Patients and Methods: Eighty-four consecutive patients with malignancy were included in this study. The levels of plasma and bone marrow VEGF and Ang2 were analyzed by enzyme-linked immunosorbent assay.

Results: The levels of VEGF were higher in patients with solid tumors than in patients with leukemias (P=0.003), whereas Ang2 concentrations showed the opposite (P=0.003). Interestingly, the plasma concentrations of both VEGF and Ang2 correlated with concentrations in the bone marrow (P<0.05). Leukemia patients with lower VEGF level and patients with higher Ang2 level at follow-up had longer event-free survival than other patients (P=0.032 and 0.053, respectively).

Discussion: The results of our study enlighten the behavior of 2 different angiogenic factors in pediatric patients with malignancy. An interesting finding was the connection between survival of pediatric leukemia patients and angiogenic factor levels a few months after the beginning of therapy. Pathophysiology and clinical applications of these findings need further studies.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

Twitter
twitter.com/JPHOonline

For additional oncology content, visit LWW Oncology Journals on Facebook.