Skip Navigation LinksHome > October 2012 - Volume 34 - Issue 7 > Neonatal Alloimmune Neutropenia: Still a Diagnostic and The...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318266c3b5
Original Articles

Neonatal Alloimmune Neutropenia: Still a Diagnostic and Therapeutical Challenge

Águeda, Sofia MD*; Rocha, Gustavo MD*; Ferreira, Fátima MD; Vítor, Bonito MD; Lima, Margarida MD§; Guimarães, Hercília PhD*,∥

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Abstract

Objective: To describe a case of neonatal alloimmune neutropenia (NAN), a very rare disease of the newborn and the first ever reported in our neonatal intensive care unit, with emphasis in its management and outcome.

Description: We report a case of NAN due to anti-human neutrophil antigen-1b alloimmunization in a 29-week preterm admitted to our neonatal intensive care unit. In this case, the neutropenia was severe and persisted for almost 2 months. There was a good response to the administration of intravenous immunoglobulin.

Comments: NAN is caused by maternal production of neutrophil-specific alloantibodies in response to antigens from paternal heritage present on the newborn neutrophiles. The course of the disease is usually mild and self-limiting. The optimal therapy is yet a debate, with some authors finding the use of intravenous immunoglobulin effective, prophylactic antibiotic therapy or recombinant human granulocyte colony-stimulating factor.

© 2012 Lippincott Williams & Wilkins, Inc.

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