Immune Function in Newly Diagnosed Children With MalignancyWiegering, Verena MD; Schlegel, Paul-Gerhardt MD; Winkler, Beate MDJournal of Pediatric Hematology/Oncology: October 2012 - Volume 34 - Issue 7 - p 559–564 doi: 10.1097/MPH.0b013e3182580457 Clinical and Laboratory Observations Abstract Author Information Background: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis. Methods: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA. Observations: We detected higher values of CD4+ T cells and consecutively shifted CD4+/CD8+ ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations. Conclusions: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches. Department of Pediatric Hematology and Oncology, University Children’s Hospital Wuerzburg, Wuerzburg, Germany Supported by a program project grant (Z-2/7-28.06.04.) of IZKF Wuerzburg and in part by a grant from the Tour of Hope Foundation (2007). The authors declare no conflict of interest. Reprints: Verena Wiegering, MD, Department of Pediatric Hematology and Oncology, University Children’s Hospital Wuerzburg, Josef-Schneiderstr. 2, D-97080 Wuerzburg, Germany (e-mail: email@example.com). Received October 13, 2011 Accepted March 29, 2012 Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.