Skip Navigation LinksHome > October 2012 - Volume 34 - Issue 7 > Immune Function in Newly Diagnosed Children With Malignancy
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182580457
Clinical and Laboratory Observations

Immune Function in Newly Diagnosed Children With Malignancy

Wiegering, Verena MD; Schlegel, Paul-Gerhardt MD; Winkler, Beate MD

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Abstract

Background: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.

Methods: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.

Observations: We detected higher values of CD4+ T cells and consecutively shifted CD4+/CD8+ ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.

Conclusions: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.

© 2012 Lippincott Williams & Wilkins, Inc.

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