Skip Navigation LinksHome > October 2012 - Volume 34 - Issue 7 > Gemcitabine, Docetaxel, and Bevacizumab in Relapsed and Refr...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31826b9d25
Clinical and Laboratory Observations

Gemcitabine, Docetaxel, and Bevacizumab in Relapsed and Refractory Pediatric Sarcomas

Hingorani, Pooja MD; Eshun, Francis MD; White-Collins, Andrea PNP; Watanabe, Masayo MD

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Abstract

Background: The outcome for patients with relapsed and refractory pediatric sarcomas remains dismal. Novel agents are needed to improve overall survival in these patients.

Observations: We present 3 patients with relapsed/refractory sarcomas treated with gemcitabine, docetaxel, and bevacizumab in 3-week cycles. The combination was well tolerated with minimal toxicity. Two patients had a partial response and the third patient had stable disease for >6 months.

Conclusions: These results are limited by small patient numbers but this strategy should be evaluated in prospective clinical trials.

© 2012 Lippincott Williams & Wilkins, Inc.

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