Skip Navigation LinksHome > August 2012 - Volume 34 - Issue 6 > Severe Transient Left Ventricular Pseudohypertrophy During T...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318257a4cb
Clinical and Laboratory Observations

Severe Transient Left Ventricular Pseudohypertrophy During Treatment of Hemophagocytic Lymphohistiocytosis: A Case Report

Kuzmanovic, Milos MD*; Pasic, Srdjan MD, PhD; Prijic, Sergej MD; Jovanovic, Ankica MD§; Kosutic, Jovan MD, PhD

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Abstract

Background: An association between hemophagocytic lymphohistiocytosis (HLH) and severe transient left ventricular (LV) hypertrophy has not been described to date. Possible explanations, including etoposide toxicity, are discussed.

Observation: A 2-month-old male infant with HLH was treated according to the HLH-2004 protocol. Initial cardiac evaluation was within normal limits. During the second month of therapy, a heart murmur was discovered; electrocardiogram demonstrated signs of LV hypertrophy, and echocardiogram confirmed the presence of thickness of LV walls. This complication was transient: clinical findings, echocardiogram, and electrocardiogram recorded 6 months afterward were all within normal limits.

Conclusions: The case suggests the need for close echocardiographic monitoring during HLH treatment.

© 2012 Lippincott Williams & Wilkins, Inc.

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