Skip Navigation LinksHome > August 2012 - Volume 34 - Issue 6 > Risk Factors for Early Death in Transient Myeloproliferative...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318249597f
Clinical and Laboratory Observations

Risk Factors for Early Death in Transient Myeloproliferative Disorder Without Phenotypic Features of Down Syndrome: A Case Report and Literature Review

Kawase, Koya MD*; Azuma, Eiichi MD, PhD; Ohshita, Hironori MD*; Tanaka, Tatsushi MD*; Hanada, Yu MD*; Sasaki, Tomoaki MD*; Sugimoto, Mari MD*; Togawa, Takao MD*; Kouwaki, Masanori MD, PhD*; Ito, Tsuyoshi MD, PhD*; Hirayama, Masahiro MD, PhD; Koyama, Norihisa MD, PhD*

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Abstract

Not only in newborns with Down syndrome, but newborns without phenotypic features of Down syndrome also develop transient myeloproliferative disorder (TMD). In these cases, trisomy 21 and related chromosomal abnormalities are either constitutionally mosaic or limited to blood cells. Risk factors for early death of these patients are unknown so far. We here report a fatal case of TMD without phenotypic features of Down syndrome and review literature to identify risk factors associated with early death. Not only are gestational age and white blood cell count risk factors for early death in TMD with Down syndrome, but they also appear to be risk factors in TMD without Down syndrome.

© 2012 Lippincott Williams & Wilkins, Inc.

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