Not only in newborns with Down syndrome, but newborns without phenotypic features of Down syndrome also develop transient myeloproliferative disorder (TMD). In these cases, trisomy 21 and related chromosomal abnormalities are either constitutionally mosaic or limited to blood cells. Risk factors for early death of these patients are unknown so far. We here report a fatal case of TMD without phenotypic features of Down syndrome and review literature to identify risk factors associated with early death. Not only are gestational age and white blood cell count risk factors for early death in TMD with Down syndrome, but they also appear to be risk factors in TMD without Down syndrome.
*Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Aichi
†Department of Pediatrics and Cell Transplantation, Mie University Graduate School of Medicine, Mie, Japan
The authors declare no conflict of interest.
Reprints: Koya Kawase, MD, Department of Pediatrics, Toyohashi Municipal Hospital, 50 Aza Hachiken Nishi, Aotake-Cho, Toyohashi, Aichi 441-8570, Japan (e-mail: firstname.lastname@example.org).
Received September 26, 2011
Accepted January 3, 2012