Skip Navigation LinksHome > August 2012 - Volume 34 - Issue 6 > Acute Monoblastic Leukemia That Switched Lineage at Relapse...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e318233219d
Online Articles: Clinical and Laboratory Observations

Acute Monoblastic Leukemia That Switched Lineage at Relapse to Acute Lymphoblastic Leukemia: A Case Report

Inoue, Akiko MD, PhD; Kawakami, Chihiro; Takitani, Kimitaka; Ikemoto, Toshiyuki; Tamai, Hiroshi

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We herein present the case of an acute monoblastic leukemia infant who relapsed with acute lymphoblastic leukemia (ALL). Complete remission was achieved after an acute myeloblastic leukemia-directed chemotherapy, but the patient relapsed with pro-B ALL. As he did not respond to acute myeloblastic leukemia-type reinduction therapy, he was switched to ALL-type chemotherapy, and a complete remission was achieved. Unrelated cord blood stem cell transplantation was performed, but he relapsed with pro-B ALL again. After he received ALL-type chemotherapy, he underwent another bone marrow transplant from his human leukocyte antigen mismatch mother, and has been free from recurrence for over 8 months.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


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