Hypocellular acute myeloid leukemia (AML) is extremely rare in childhood. We report on a 7-year-old girl with hypocellular AML who was treated successfully with granulocyte-colony stimulating factor (G-CSF) and combined chemotherapy. High-dose G-CSF induced complete remission and she subsequently received reduced intensity conditioning and unrelated cord blood transplantation; however, this resulted in early rejection. After a complete hematological recovery, she received 3 courses of combination chemotherapy oriented toward AML. She has remained in complete remission for over 1 year after the completion of the therapy. G-CSF effectively induced remission, and combination chemotherapy has been proven to be feasible for patients with childhood hypocellular AML.
*Department of Pediatrics
†Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo
‡Department of Laboratory Medicine, Tokai University School of Medicine, Kanagawa
§Department of Pathology, Japanese Red Cross, Nagoya Daiichi Hospital, Nagoya, Japan
Author contribution: Masaki Yamamoto, Hiroyuki Tsutsumi, Naoki Hatakeyama, Keita Igarashi, Kotoe Iesato, and Nobuhiro Suzuki treated the patient. Masaki Yamamoto, Hiroyuki Tsutsumi, and Nobuhiro Suzuki wrote the paper. Katsuya Nakanishi, Hiroko Noguchi, Hayato Miyachi, and Masafumi Ito contributed to the pathological diagnosis. Nobuhiro Suzuki, Naoki Hatakeyama, KI, and Hiroyuki Tsutsumi contributed vital new reagents or analytical tools.
This case was presented at the 52th Annual Meeting of the Japanese Society of Pediatric Hematology, December 16 to 18, 2010, Osaka, Japan.
The authors declare no conflict of interest.
Reprints: Masaki Yamamoto, MD, Department of Pediatrics, Sapporo Medical, University School of Medicine, S1W16 Chuo-ku, Sapporo, 060-8543, Japan (e-mail: firstname.lastname@example.org).
Received March 29, 2011
Accepted September 19, 2011