Skip Navigation LinksHome > July 2012 - Volume 34 - Issue 5 > Successful Treatment of Childhood Hypocellular Acute Myeloid...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182388966
Clinical and Laboratory Observations

Successful Treatment of Childhood Hypocellular Acute Myeloid Leukemia

Yamamoto, Masaki MD*; Hori, Tsukasa MD, PhD*; Hatakeyama, Naoki MD, PhD*; Igarashi, Keita MD*; Iesato, Kotoe MD*; Nakanishi, Katsuya MD, PhD; Noguchi, Hiroko MD, PhD; Miyachi, Hayato MD, PhD; Ito, Masafumi MD, PhD§; Tsutsumi, Hiroyuki MD, PhD*; Suzuki, Nobuhiro MD, PhD*

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Abstract

Hypocellular acute myeloid leukemia (AML) is extremely rare in childhood. We report on a 7-year-old girl with hypocellular AML who was treated successfully with granulocyte-colony stimulating factor (G-CSF) and combined chemotherapy. High-dose G-CSF induced complete remission and she subsequently received reduced intensity conditioning and unrelated cord blood transplantation; however, this resulted in early rejection. After a complete hematological recovery, she received 3 courses of combination chemotherapy oriented toward AML. She has remained in complete remission for over 1 year after the completion of the therapy. G-CSF effectively induced remission, and combination chemotherapy has been proven to be feasible for patients with childhood hypocellular AML.

© 2012 Lippincott Williams & Wilkins, Inc.

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