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A Translocation t(5;15)(q15;q11-13) Infant Case with Acute Lymphoblastic Leukemia and Literature Review: Prognosis Implications

Corona-Rivera, Alfredo PhD; Bobadilla-Morales, Lucina PhD; Cruz-Osorio, Rosa Margarita MD; Ortega-de-la-Torre, Citlalli PhD; Gallegos-Castorena, Sergio MD; Sánchez-Zubieta, Fernando MD

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e31824258f2
Original Articles
Abstract

Infant acute lymphoblastic leukemia (ALL) represents poor prognosis despite intensive chemotherapy. Rearrangements of chromosome 11q23 are not observed in 34% of the cases. Infant ALL patients with t(5;15)(p15;q11-13) are rare and sporadic. In large series of infant ALL studies, 6 patients have been reported. We present a new case of an infant ALL patient with t(5;15)(p15;q11-13), and a literature review. Considering the data provided by our case and previous reports, we reinforce that this chromosomal abnormality is characteristic of ALL patients under 12 months of age sharing break point in 5p15 and 15q11-13 and strengthen the existence of an infant ALL subgroup characterized by pre-B L1 ALL, CD10-positive, complete remission (100%), and event-free survival (71%), with a relatively good prognosis and clearly less severe than the 11q23 rearrangement cases. This abnormality can be considered a recurrent abnormality on this nosologic group.

Author Information

*Unidad de Citogenética/Servicio de Hematología Oncología Pediátrica, División de Pediatría, Nuevo Hospital Civil “Dr Juan I. Menchaca”

Laboratorio de Citogenética Genotoxicidad y Biomonitoreo, Instituto de Genética Humana “Dr ECR”, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud/Doctorado en Genética Humana, Universidad de Guadalajara, Guadalajara, Jalisco, México

The authors declare no conflict of interest.

Reprints: Alfredo Corona-Rivera, PhD, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Instituto de Genética Humana “Dr Enrique Corona Rivera”, Laboratorio de Citogenética Genotoxicidad y Biomonitoreo, Edificio P 2do Nivel, Sierra Mojada #950, S.L., CP-44340 Guadalajara, Jalisco, México (e-mail: alcoronar@gmail.com).

Received June 30, 2011

Accepted November 16, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.