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Serum Levels of Mannose-Binding Lectin and the Risk of Infection in Pediatric Oncology Patients With Chemotherapy

Ghazi, Mona PhD; Isadyar, Mina MD; Gachkar, Latif MD; Mahmoudi, Shima MSc; Goudarzi, Hossein PhD; Eslami, Gita PhD; Pourakbari, Babak PhD; Fallah, Fatemeh PhD

Journal of Pediatric Hematology/Oncology: March 2012 - Volume 34 - Issue 2 - p 128–130
doi: 10.1097/MPH.0b013e31822bf7d3
Original Articles

Morbidity and mortality due to infections remain serious problems in pediatric oncology patients receiving chemotherapy. Association of mannose-binding lectin (MBL) levels with an increased risk for infection in previous studies was contradictory. The aim of this study was to determine whether MBL deficiency is associated with the risk of infections in pediatric oncology patients. Before the start of chemotherapy a blood sample was taken from 75 patients with acute lymphoblastic leukemia and MBL serum concentration was measured using a commercially enzyme-linked immunosorbent assay kit. Twenty patients had concentrations under 1000 µg/L, defining MBL deficiency and the remaining 55 patients had concentrations >1000 µg/L. Ten patients suffered from more than 1 episode of severe infection. Sixty-five percent of patients with MBL below 1000 µg/mL suffered from 2 or more episodes of infections (3 of 16 individuals with 1 severe infection; 10 of 16 with 2 and 3 of 16 with 3), in contrast to only 29 of 55 (52%) patients with MBL above 1000 µg/mL (19 of 27 individuals with 1 severe infection and 10 of 27 with 2). The difference between 2 groups was significant (P<0.001). The results of this study indicate that low MBL serum levels (<1000 µg/L) identify pediatric cancer patients at increased risk for infections.

*Department of Microbiology, School of Medicine, Shahid Beheshti Medical Sciences University, Tehran, Iran

Infectious and Tropical Diseases Research Center, Shahid Beheshti Medical Sciences University, Tehran, Iran

Department of Pediatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

§Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

The authors declare no conflict of interest.

Reprints: Fatemeh Fallah, PhD, Address: No. 1, Kodakyar Alley, Daneshjou Boulevard. Pediatric Infectious Research Center, Shahid Beheshti Sciences Medical University, Tehran, Iran (e-mail: dr_fallah@yahoo.com).

Received February 28, 2011

Accepted June 22, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.