Skip Navigation LinksHome > March 2012 - Volume 34 - Issue 2 > Myelofibrosis: A Cause of Increased Transfusion Requirement...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182278266
Clinical and Laboratory Observations

Myelofibrosis: A Cause of Increased Transfusion Requirement in a Child With β-Thalassemia Intermedia

Nirupam, Nilay MD*; Maheshwari, Anu MD*; Rath, Bimbadhar MD*; Chandra, Jagdish MD*; Kumar, Praveen MD*; Basu, Srikanta MD*; Nangia, Anita MD

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Abstract

A 10-year-old girl presented with gradually increasing pallor and abdominal distension for 1 year and fever for 6 months. She required 3 packed cell transfusions during this interval. Investigations done revealed that the child had thalassemia intermedia and parents were carrier of β-thalassemia gene. The increased transfusion requirement in this case prompted further investigations, which revealed the presence of myelofibrosis. Case reports of myelofibrosis and myelodysplastic syndromes with acquired hemoglobin disorders exist in literature, especially α-thalassemia. To the best of our knowledge, this is the first reported case of β-thalassemia intermedia in association with myelofibrosis.

© 2012 Lippincott Williams & Wilkins, Inc.

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