A 10-year-old girl with multiple persistent ganglioneuromas originating from the spontaneous maturation of a metastatic neuroblastoma is described. Multiple biopsies confirm progressive maturation and urine catecholamines, which were initially elevated, have normalized over time. The management and risk of malignant transformation of ganglioneuromas is discussed.
*Division of Hematology/Oncology/BMT
†Division of Pediatric General Surgery, Department of Pediatrics, Faculty of Medicine, University of British Columbia/BC Children's Hospital, Vancouver, British Columbia, Canada
The authors declare no conflict of interest.
Reprints: Jacob Rozmus, MD, Division of Hematology/Oncology/BMT, BC Children's Hospital, Room A119, 4480 Oak St, Vancouver, BC V6H 3V4, Canada (e-mail: firstname.lastname@example.org).
Received September 28, 2010
Accepted April 27, 2011