Skip Navigation LinksHome > March 2012 - Volume 34 - Issue 2 > Cyto-Morphologic Evaluation of Bone Marrow in Infants With D...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182281dc3
Clinical and Laboratory Observations

Cyto-Morphologic Evaluation of Bone Marrow in Infants With Disseminated Neuroblastoma

Sorrentino, Stefania MD; Rosanda, Cristina PhD; Parodi, Stefano PhD; Rita Gigliotti, Anna MD; Pasino, Mirella PhD; Defferrari, Raffaella PhD; Paolo Tonini, Gian PhD; De Bernardi, Bruno MD

Supplemental Author Material
Collapse Box


We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.