Skip Navigation LinksHome > March 2012 - Volume 34 - Issue 2 > Cyto-Morphologic Evaluation of Bone Marrow in Infants With D...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3182281dc3
Clinical and Laboratory Observations

Cyto-Morphologic Evaluation of Bone Marrow in Infants With Disseminated Neuroblastoma

Sorrentino, Stefania MD*; Rosanda, Cristina PhD*; Parodi, Stefano PhD; Rita Gigliotti, Anna MD*; Pasino, Mirella PhD*; Defferrari, Raffaella PhD; Paolo Tonini, Gian PhD; De Bernardi, Bruno MD*

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Abstract

We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.

© 2012 Lippincott Williams & Wilkins, Inc.

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