Skip Navigation LinksHome > August 2010 - Volume 32 - Issue 6 > Utility of Cerebrospinal Fluid Cytology in Newly Diagnosed C...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0b013e3181d7adf5
Clinical and Laboratory Observations

Utility of Cerebrospinal Fluid Cytology in Newly Diagnosed Childhood Ependymoma

Moreno, Lucas MD*; Pollack, Ian F. MD; Duffner, Patricia K. MD; Geyer, J. Russell MD§; Grill, Jacques MD, PhD; Massimino, Maura MD; Finlay, Jonathan L. MD; Zacharoulis, Stergios MD*

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Abstract

The role of cytology of cerebrospinal fluid (CSF) has not been established in pediatric ependymoma. Thirty-two children with metastatic ependymoma were analyzed: 11 patients had only positive CSF cytology, 6 had only positive magnetic resonance imaging (MRI) findings, and 15 had both CSF cytology and MRI positive. Twenty-two patients relapsed. Five-year event-free survival was 27.3%±13.4% for children with only CSF positive (M1) versus 26.1%±10.2% for patients with positive spine MRI positive (with or without CSF positive, M3) (P=0.87). In conclusion, 34% of the patients with metastatic ependymoma were identified based on CSF cytology only and their outcome was comparable to patients with macroscopic disease. CSF cytology is a useful tool to stage newly diagnosed patients with ependymoma.

© 2010 Lippincott Williams & Wilkins, Inc.

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